Polynucleotides in injection cosmetology. Preparations, prices, where to buy

Biopolymers, or polynucleotides, are an innovative material for rejuvenation and deep recovery programs in injection cosmetology. Thanks to high molecular weight organic biocompounds that play an important biological role in the body, it is possible to prevent the development of signs of aging, to solve a number of aesthetic problems without plastic surgery.

Before making a decision to conduct polynucleotide anti-age therapy, it is necessary to familiarize yourself with the types of drugs, indications and contraindications, as well as the peculiarities of injection procedures.

What are polynucleotides

Polynucleotides in injection cosmetology and medicine are essentially biopolymers of natural or synthetic origin, consisting of nucleotide or mononucleotide residues. Their main function is to ensure the safety, implementation with the subsequent transfer of genetic information. Low molecular weight compounds are used in cosmetology.

By their natural structure, polynucleotides (PDRN) are one of the fragmentary parts of the DNA molecule with its multidirectional beneficial properties that affect all the most important processes in the cells of the body.

According to studies, the use of low molecular weight DNA, devoid of genetic information and not exceeding 500 KDa, is safe, since it does not cause genetic transformations.

In the course of testing the first samples of polynucleotide compositions in cosmetology, the effectiveness of the drugs was confirmed, a positive effect on the composition of cells and intradermal structures was noted. For innovative booster drugs, the necessary compounds are synthesized from organic matter.

In production, an extract from the DNA of the gonadal tissues of male salmonids is used. It has been confirmed that the DNA of milk is similar to the DNA of human leukocytes in structure and properties. For this reason, the elements synthesized for cosmetology have a positive effect.

The vitamin and structural composition of milk is rich in nucleic acids, protein proteins, which are actively used in the field of medicine and cosmetology. Such booster drugs practically do not cause negative manifestations, allergies after a course of injections, their safety for the human body has been confirmed.

Indications for the use of polynucleotides in injection cosmetology

A number of aesthetic problems can be solved by injection therapy with nucleotide drugs:

• eliminate wrinkles of all types, as well as suspend the formation of new ones;
• get a powerful lifting effect;
• return the elasticity, elasticity lost under the influence of external and age factors;
• activate fibroblasts for accelerated synthesis of collagen-elastin fibers;
• smooth out the skin relief by restoring the intradermal layers;
• restore the hydrobalance of the epidermis, moisturize internal tissues;
• eliminate inflammatory processes, speed up the healing process;
• eliminate stretch marks, post-acne marks, scars and scars;
• enhance metabolism in tissues to strengthen the skin structure;
• remove toxins and toxins, improve complexion;
• to tighten the skin, eliminate signs of gravitational ptosis, rosacea.

Injection therapy with polynucleotide drugs is used for bio-reinforcement, is effective for fine-wrinkled aging with thinned, moisture-free, sagging skin. The technique provides sustainable protection from free radicals and ultraviolet radiation, preventing photoaging, increasing the stress resistance of the skin.

Such acids in cosmetology are called "smart", they are able to fight for youth, restoring damaged DNA and stimulating all the most important physiological processes. As a result of such activation by injecting drugs with polynucleotides in the body, the mechanism of self-rejuvenation is triggered.

Possibilities of polynucleotides in activating the work of skin cells

Polynucleotides are an innovative and effective solution in correction and rejuvenation programs. In injection cosmetology, preparations with polynucleotides, in terms of the strength of the effect obtained, in some cases surpass most of the methods of the beauty industry. This result is achieved through the renewal of tissues at the DNA level.

The newly formed cellular compounds replace the damaged nitrogenous bases, activating the process of rejuvenating the skin and the whole organism. The effectiveness and potential of the drugs at the stage of preclinical studies were studied in a test system, which is a culture of epidermal cells.

The following was revealed:

• With the introduction of drugs intradermally, there is an active effect of the entire complex on cellular metabolism.
• The synthesis of proteins inside DNA cells is accelerated by more than 2 times. The expressiveness of the aesthetic result can be more pronounced if a highly concentrated polynucleotide composition is used.
• The obtained result of cellular stimulation spreads through the formation of immunocompetent epidermal cells, which has a positive effect not only on the state of the epidermis, but also on the entire immune system in general.

Polynucleotides in aesthetic cosmetology are classified as "prodrugs" that are capable of supplying cells with mitogenic deoxyribonucleotides, deoxyribonucleosides, and nitrogenous bases.

The use of the injection technique with compositions based on polynucleotides is considered one of the most promising directions in the field of complex rejuvenation, correction of pronounced signs of chrono- and photoaging.

Contraindications and safety of injections with PDRN

Despite the proven safety for the body, there are a number of contraindications to the use of the injection technique based on polynucleotide acids.

Therapy is not recommended for:

• under the age of 18;
• with diabetes mellitus in the decompensation stage;
• in case of signs of rheumatoid changes with damage to the connective tissue;
• in the presence of autoimmune, infectious and viral diseases;
• with mechanical damage, inflammation of the skin in the area of ​​injection;
• in the presence of malignant neoplasms;
• during pregnancy and lactation;
• with acute intolerance to the components of the drug.

It is not recommended to carry out intradermal injection therapy if there are signs of hemophilia and the patient is taking medications that affect blood clotting.

In general, the safety of the drugs is clinically proven.

Anti-aging polynucleotide formulations do not cause:

• acute allergic reactions;
• toxicity;
• genetic transformation.

Before the injection sessions, a qualified cosmetologist identifies any contraindications, and with the slightest doubts about safety, he can recommend the consultation of a narrow specialist.

Injection with polynucleotides and hyaluronic acid

Polynucleotides in injection cosmetology, as well as hyaluronic acid, are highly effective drugs for anti-age programs. The decision on the use of a particular composition is made by the cosmetologist after consultation, examination, analysis and assessment of the aesthetic problem.

The main differences in the mechanism of action on the dermal space are presented in the table:

One of the main differences between hyaluronate in boosters is that polynucleotides increase the number of dermal structures by a natural physiological effect, providing a prolonged result.

By activating the functional and reparative properties of skin structures, polynucleotide formulations of drugs provide activation of the process of their own biorevitalization and bioreparation.

Despite some differences, the substances are "friendly", which is why most beauty products for injectable anti-aging therapy use the synergy of hyaluronate and polynucleotides. This composition allows you to achieve the most visible and lasting effect of rejuvenation, since one of the properties of polynucleotides is to enhance the action of hyaluronic acid.

The effectiveness of anti-aging injections with polynucleotides

The main characteristics of smart acids that are valued in the beauty industry are:

• Stimulation of fibroblasts.
• Activation of neocollagenesis with the synthesis of new collagen molecules.
• Stimulating the production of your own nucleic acid.
• Improving the regenerative properties of internal tissues.
• Activation of the process of re-utilization of the skin's own nucleotides.

Thanks to these properties, the following effectiveness of anti-aging injections with polynucleotides is noted:

• bioreparation is stimulated;
• re-epithelialization, scarring of the skin is accelerated;
• normalization and acceleration of the formation of granulation tissues is ensured;
• metabolic cellular activity increases;
• angiogenesis is stimulated;
• the effect of moisturizing with hyaluronic acid is enhanced;
• the degree of the pro-inflammatory cytokine TNFa decreases.

Polynucleotides are biological traps that prevent the penetration of free radicals and protect cellular structures from various damage. They provide long lasting UV protection.

Polynucleotide-based preparations

Polynucleotides in injection cosmetology are used as monotherapy in rejuvenation programs or in synthesis with other active substances. Manufacturers offer several types of drugs, the action of which is aimed at solving a particular set of aesthetic problems.

All compositions have a dense gel structure, are plastic, safe, practically do not cause side reactions. The sessions are conducted by qualified cosmetologists in the salon or in a clinical setting.

The most popular drugs with polynucleotides:

• NEWEST. It is used to correct age-related changes, strengthens tone, restores elasticity to the epidermis, healing from the inside at the cellular level. The average cost of 2 ml of the drug is from 5300 rubles.
• PLINEST FAST. A fast-acting composition, suitable for young skin prone to frequent stress, with a fine wrinkled type of aging. The composition is non-toxic to the cell structure, biocompatible with internal tissues. Allows to eliminate traces of early wilting, the effect of stressed skin, flabbiness, atony. The average cost in specialized stores is 7800 rubles.
• Renaissance System-1. A biological product with a polynucleotide complex helps to thicken the thinned, moisture-free skin, replenish tissue volume, and perform bio-reinforcement in order to activate neocollagenesis in the body. The cost of the procedure with the drug (1 ml) - from 9700 rubles.
• TwAc and TwAc 3.0. A popular booster in cosmetology, it is used for thickening, rejuvenation, activation of cellular processes, renewal of dermal structures. Tweiss has a stimulating, immune-strengthening effect, in the composition of polydeoxyribonucleotides and stabilized hyaluronate. The complex of beneficial acids allows you to solve a number of aesthetic problems in various different areas of the body and face. The average cost of a booster is from 5500 rubles.
• PLINEST BODY. Intradermal pyrogen-free gel of a liquid consistency is intended for the correction of problem areas of the body. It can be used in the area of ​​the buttocks, neck, décolleté, as well as in trichology to restore the scalp. The price of one package (5 ampoules) is from 6000 rubles.

One or another composition can be used for different purposes:

• to boost the skin;
• to correct the periorbital zone;
• in biorevitalization programs;
• for rejuvenation.

The drug is selected and prescribed by a beautician according to individual indications.

For skin boosting

The booster system based on preparations with polynucleotides allows:

• provide maximum rehydration;
• improve turgor, increase elasticity, restore firmness and tone;
• provide protection against the negative effects of free radicals that destroy the cellular structure;
• stimulate dermal regeneration;
• activate the metabolism of fibroblasts.

The booster system allows you to improve the condition of the skin, thickening the tissues, restoring the lost volume as a result of processes that destroy the cellular base. The most effective booster is TwAc 2.0, 3.0 with the synthesis of hyaluronate and polynucleotides.

For the skin around the eyes

In the process of photo- or chrono-aging, the periorbial zone is most susceptible to negative changes. Thinned, dehydrated and susceptible to the formation of a network of wrinkles can be restored with the polynucleotide preparation TwAc Eyes. It is a sterile, odorless, colorless gel-like solution based on a long-chain polynucleotide.

It allows you to:

• supply cells with a sufficient amount of mitogenic deoxyribonucleotides, deoxyribonucleosides and nitrogenous bases;
• improve the regenerating properties of the epidermis;
• increase metabolism in cells;
• tighten and smooth the eye area, décolleté and neck.

For biorevitalization

Polynucleotides are used in cosmetology for biorevitalization.

The procedures allow:

• restore the integrity of the matrix structure;
• enhance the function of fibroblasts to activate neocollagenesis;
• to correct and prevent ptosis;
• reduce the severity of dermal and epidermal wrinkles.

As a rule, for biorevitalization, combined formulations with polynucleotides and hyaluronate are used. The most effective boosters are TwAc, as well as Renaissance.

For skin rejuvenation

For total rejuvenation of aging skin with visible changes, cosmetologists recommend using injections with Plinest.

Injection therapy for rejuvenation allows:

• revitaminize tissues;
• heal, strengthen the skin's immunity;
• eliminate strong visible changes, hyperpigmentation; smooth out medium and deep wrinkles;
• eliminate signs of gravitational ptosis and other changes due to aging.

For a more pronounced and lasting result, it can be used as a hyaluronic acid enhancer, used in anti-age programs from 45 years old.

Procedure with polynucleic acids

A session of rejuvenation, biorevitalization or boosterization with boosters based on polynucleotides is carried out in several stages:

1. First, the cosmetologist conducts a consultation, examination, collection of anamnesis. Determines the area in need of correction, selecting the optimal drug and dosage.
2. Before injections, he removes makeup, cleanses and disinfects the skin.
3. To anesthetize the most sensitive areas, she uses application anesthesia so that the session does not cause discomfort.
4. He starts intradermal injection of the drug with a special medical needle for cosmetological injections, pointwise treating the entire problem area.
5. Applies a healing ointment for faster recovery from an invasive procedure.

A rejuvenation session with polynucleotides takes no more than 60 minutes. The effect can be felt 4-7 days after the first injection. The recommended course for the correction of aesthetic problems is determined by the cosmetologist. The interval between sessions of intradermal injection of the drug is 7-14 days.

After 6-12 months, it is recommended to repeat the course to achieve a more stable and long-term effect.

To solve various problems, as well as to prevent aging, polynucleotides are used in injection cosmetology. The cost of the course depends on the type of drug, as well as on the qualifications of the cosmetologist and the correction zone.

Useful videos about polynucleotides in injection cosmetology and their effectiveness

How polynucleotides are used in cosmetology:

How polynucleotides work: