Longidase is a broad-spectrum enzyme preparation that is safe and well tolerated. The application guide assumes the release of the drug in the form of injections, providing a quick and long-term therapeutic effect.
Release form and composition
Longidaza (injections), the instructions for the use of which have their own characteristics, is available in the form of a powder for injection. It is a white or yellow / brown mass.
The medicinal product is made by lyophilization - soft drying that preserves bioactivity for a long time. When a hygroscopic (moisture-absorbing) powder is diluted, the beneficial properties are completely restored.
The active ingredient is longidase - a natural enzyme hyaluronidase associated with a base (azoxymer bromide). The product is produced in ampoules or vials containing 15 or 20 mg each.
Each ampoule (bottle), depending on the dosage, contains:
| Weight of powder in a bottle | Content of the main substance - longidase (stated dosage) | Auxiliary component - mannitol |
| 15 mg | 1500 IU | To the required volume (up to 15 or 20 mg) |
| 20 mg | 3000 IU |
1 carton contains 5 vials (ampoules).
Efficiency
The wide range of applications of Longidase is due to the safety and therapeutic effect that persists for a long time.
Among the positive aspects of the drug's effects:
- fight against edema and hematomas, scars and adhesions - by improving cell permeability and nutrition;
- suppression of inflammation in the acute phase - injections are especially effective at the beginning of the development of the pathological process;
- increased immunity and resistance to infections;
- prevention of fibrosis (proliferation of connective tissue) - the formation of rough scars and adhesions in the postoperative period, an increase in organs of a non-tumor nature;
- improving joint mobility;
- increasing the elasticity of the skin - by activating the production of collagen;
- ensuring the full assimilation of other injections, including accelerating the action of local anesthetics;
- reducing the activity of free radicals - antioxidant effect.
In this case, Longidaza:
- differs in insignificant toxicity;
- does not adversely affect immunity and reproductive function;
- rarely leads to allergies or irritation;
- does not inhibit the rehabilitation and restoration of bone tissue after surgical procedures;
- not dangerous from the point of view of gene mutations or malignant transformations.
Mannitol, included in Longidase, has a diuretic effect, relieves swelling.
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Longidaza (injections) are included in the complex of treatment and prevention of conditions accompanied by the proliferation of the connective tissue membranes of organs, joints and skin.
The drug is administered to adults for diseases related to the field:
- gynecology: for the treatment and prevention of chronic tissue proliferation or adhesions of the uterine mucosa, adhesions obstruction of the fallopian tubes;
- urology: in the treatment of chronic inflammation of the prostate gland, interstitial cystitis (especially when it is caused by immune disorders or loss of the protective layer of the bladder mucosa);
- surgical practice: to eliminate and prevent adhesive manifestations after manipulations on the abdominal cavity, as well as slowly healing wounds;
- orthopedics and rheumatology: with insufficient mobility of the joints due to the presence of scars (contractures - flexion carpal and Dupuytren), inflammation of the articular tissues, ankylosing spondylitis (damage to the vertebral cartilage), hematomas;
- pulmonology and phthisiology: in the treatment of pneumofibrosis, lesions of the alveoli and the capillary network of the lungs, forms of tuberculosis, accompanied by the formation of cavities with a fibrous capsule (cavernous fibrous, infiltrative, tuberculous);
- dermatovenerology and cosmetology: with rough scarring and keloids after injuries, burns, purulent skin inflammations, acne (post-acne) or surgical interventions, areas of scleroderma, onychodystrophy of the nails of a non-infectious nature.
In these areas of medicine, Longidaza is also administered together with antibacterial or anesthetic drugs, activating their action.
Removal of hyaluronic acid gel with Longidaza:
Contraindications
Longidaza (injections), the instructions for use of which determine the drug as well tolerated, has a number of limitations in use.
Among the absolute contraindications:
- hypersensitivity to the main or auxiliary components of the composition;
- a focus of bleeding in the lungs or sputum mixed with blood;
- recent hemorrhage in the vitreous region;
- violation of the kidneys (failure) - in acute course;
- the presence of foci of malignant transformation;
- pregnancy and breastfeeding;
- acute infections - in such situations, Longidaza should be supplemented with antimicrobial drugs.
Application features
The release form (powder for injection) involves the introduction of the solution under the skin (in the vicinity of the lesion or scarring) or intramuscularly.
The standard ones are:
- dosage for 1 injection - 3000 IU.
- course - 5-25 injections;
- the time interval between injections is 3-10 days.
With changes in the connective tissues of a chronic nature, it is advisable to supplement the basic course with a supporting course, in which 3000 IU is injected with an interval of 10-14 days.
There are a number of nuances of use for different diseases:
- introduction under the skin is appropriate for joint diseases, hematomas and skin lesions. With scars, intra-cicatricial injection and / or alternation of injections are possible - subcutaneous with intramuscular;
- the minimum course (5 injections) is permissible to prevent adhesion after surgical procedures in the abdominal cavity or small pelvis;
- with damage to the alveoli of the lungs and tuberculosis, long maintenance treatment is required (up to 12 months).
If necessary, to enhance the effect of antibiotics or pain relievers, ampoules of 1500 IU are more often used. The main drug is injected 10-15 minutes after the Longidase injection in the same place. Both agents should be administered in the same way - under the skin or into the muscle tissue.
The algorithm for preparing the drug is as follows:
- Powder from a vial or ampoule of 3000 IU is diluted with 1–2 ml of procaine (0.25% or 0.5%). If procaine is poorly tolerated by the patient, 0.9% sodium chloride for injection or water for injection is used. When it is required to enhance the effect of other medications, 3000 IU is diluted with 2 ml of 0.9% sodium chloride, and 1500 IU - 1 ml.
- The solvent is smoothly added to the ampoule (bottle).
- After 2-3 minutes, the solution is gently mixed, avoiding agitation and foam formation.
Intravenous injection is prohibited. The prepared solution cannot be stored.
Features of using the drug for different age groups:
- Elderly people. Good tolerability of the drug allows its prescription to patients in old age. At the same time, it is necessary to control the indicators of the general state of the body in order to avoid the development of negative reactions from organs and systems.
- During pregnancy and lactation. The introduction of the drug in the form of injections is prohibited during gestation and breastfeeding.
- In childhood. It is forbidden to use injections for the treatment of persons under the age of 18 due to the lack of clinical data.
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Clinical trials and the practice of using injections allows conclusions to be drawn about possible negative phenomena and the frequency of their development.
The manual describes the following reactions:
- on the part of the skin - redness, swelling and itching at the injection site (infrequently). Symptoms do not require treatment, disappear within 2-3 days;
- from the side of immunity - allergic manifestations (extremely rare, 1 case per 10,000 patients);
- common indicators - fever (extremely rare).
Pain often occurs at the injection site.
Overdose
The drug is safe when administered in the prescribed doses.
The intake of an excess volume of solution into the body can provoke:
- chills or fever;
- dizziness;
- migraine;
- pressure drop.
The phenomena require refusal of treatment with Longidase and taking medications to correct the symptoms.
special instructions
Longidaza - injections, instructions for the use of which require adherence to a number of rules, general and specific for this particular drug.
The patient should be aware that:
- before starting the course of injections, the patient should notify the doctor about any medications taken;
- the introduction of the drug into the area of acute inflammation of an infectious nature is unacceptable - this threatens the spread of local infection;
- the missed injection should not be compensated for by the introduction of a double dose - it is necessary to carry out the treatment in the unchanged mode prescribed by the doctor;
- the drug should be canceled immediately, without a gradual decrease in dosages;
- the development of an allergic reaction, especially not indicated in the instructions - a reason for an immediate visit to a doctor;
- the permitted interval for patients with chronic kidney failure or recent bleeding is no more than 1 injection in 7 days;
- a damaged ampoule (bottle) containing powder that does not correspond to the description (of a different color) cannot be used.
During treatment with the drug, no restrictions are imposed on the implementation of activities that require a high concentration and speed of reactions (driving and various mechanisms).
Interaction with other drugs
Longidaza is actively used in complex therapy, supplementing injections with antibacterial, antiviral, antifungal and anticancer drugs, as well as agents that directly relieve bronchospasm.
Moreover, according to the instructions:
- the combination of injections with antibiotics, local anesthetics and diuretics increases the bioavailability of drugs and enhances their effect;
- simultaneous reception with salicylates, antihistamines and hormonal drugs - cortisone, estrogens or adrenocorticotropes in large doses can reduce the enzyme activity of Longidase;
- concomitant use of Furosemide, Benzodiazepines and Phenytoin is not recommended.
Known analogues
There are no drugs with an identical active substance and effectiveness.
A similar (but not similar) therapeutic effect is provided by:
- Lidaza - the active ingredient is hyaluronidase - a natural enzyme obtained from the glands of cattle, which has not undergone special processing (unlike Longidase).Does not differ in prolonged action (injections need to be administered more often) and additional properties - antioxidant and immunomodulatory. It can be prescribed during pregnancy and lactation. The cost of 10 ampoules is about 300 rubles;
- Polyoxidonium. The active ingredient is azoxymer bromide, additionally contains mannitol, povidone and beta-carotene. The basic effect is immunomodulatory. The drug is used for tuberculosis, chronic and recurrent urogenital diseases. Polyoxidonium is allowed for children from six months of age, is contraindicated for pregnant and lactating women. The price of 10 ampoules (minimum rate) is about 1000 rubles;
- Chymotrypsin. The drug contains an enzyme from animal pancreas. Scope of application - inflammation of the gums, ENT diseases, inflammatory processes in the lungs and organs of vision. Chymotrypsin is not prescribed until the age of 18, during pregnancy and lactation. The price of 10 ampoules is about 800 rubles;
- Trypsin - similar in composition to Chymotrypsin, it is used for pulmonary, ocular and ENT diseases, including purulent inflammation and in the postoperative period. The drug dissolves scars, liquefies viscous pus. Trypsin can be administered to pregnant and lactating women. Price - 800 rubles for 10 ampoules.
All of these medicines can be purchased in powder form for preparing an injection solution.
Terms and conditions of storage
- The drug Longidaza should be stored in a dark place, protected from moisture.
- The storage temperature should not exceed 15 degrees.
- Keep out of the reach of children.
- The shelf life is 2 years from the date of production - both dates are indicated on the package.
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Powder for solution preparation can be purchased in large pharmacy chains, as well as ordered through online pharmacies. The average cost of 5 ampoules of 3000 IU is 2000 rubles.
Reviews
Doctors evaluate the drug ambiguously - some note the effectiveness of the drug in gynecology and urology, others - the complexity of an objective assessment of the result, which makes Longidaza appropriate only in combination or prevention.
Based on patient feedback, the following conclusions can be drawn:
- for urological and gynecological diseases, the drug is often prescribed in the form of suppositories. Injections are chosen in situations where it is difficult for the patient to maintain the interval (injections have a longer lasting effect);
- regardless of the form of release, Longidaza promotes the resorption of small adhesions and the elimination of tubal infertility. With large chronic adhesions, it is not always possible to do without surgery, but injections alleviate the pain syndrome;
- the drug is effective in the treatment of acute and chronic prostatitis (increases the interval between exacerbations period), as well as cystitis;
- injections go well with antibacterial agents and physiotherapy;
- 5 injections may be enough to combat non-healing postoperative wounds;
- some patients found the injections painful;
- side effects (nausea and dizziness) are rare and do not lead to treatment withdrawal;
- after the injections, bruises and slight swelling may remain, which disappear only after a week.
All patients note the high cost of treatment.Longidaza is an unparalleled natural enzyme-based drug that gives a minimum of side effects.
Injections are especially effective in preventing adhesions and scarring, and work well with antibiotics.
The drug is safe when used as directed.
Article design: Svetlana Ovsyanikova
Video on the topic: Longidaza injections, instructions for use
Longidaza drug: reviews and recommendations of a specialist:
The sister was treated with longidaza, however, not with injections, but with suppositories for adhesions. Now everything is in order, she has already given birth.
Longidaza was prescribed to me along with antibiotics when I was treating protracted cystitis, which had already spread to the kidneys. Since I was in the hospital, the antibiotics were injected with the system, and the longidase was only in the form of suppositories. Every day, one candle and so on the whole pack. I think it was this combination of drugs that helped me walk calmly on the second day without discomfort and cuts, I was discharged in a week somewhere. I finished Longidaza at home, three days later I closed my sick leave and went to work for a day. About six months have passed, now is the season for cystitis, and with me everything pah-pah-pah.
My husband was diagnosed with chronic prostatitis. As many men did not admit for a long time that it was bad for him, already when he was crushed and could not stand, then everything became clear. And why only endure the pain and endure everything on your feet? Likewise, complications are not far away, then you will be treated all your life. It is still decided if the treatment is correct. He was prescribed antibiotics, decongestants and Longidaza to stop fibrosis. They made only 10 injections, but they did not give it every day, but after 3 days. After the second, it became easier for her husband. Gone urinary problems, because we no longer swelling, faded inflammation, pain receded, perstala give in the waist and groin .. And after the course really has improved the situation. He stopped complaining of pain, he can go to the toilet normally. And even erectile function was restored.
Longidaza injections was prescribed to me for infertility, which, according to the doctors, was due to adhesions. There were two ways to restore the pipe's patency. Either lie down on the table, or first a chance without surgery, that is, injections. Of course, I chose the injections. I went to prick in their own treatment room, where I went to the gynecologist. In general, it hurts, of course, but with painkillers it is tolerable. In the end, that: the adhesions softened and the pregnancy literally two months later, and I suffered for three years with these adhesions. By the way, the pulling pains before my period have passed. The doctor said this because the adhesions stopped squeezing everything inside.
I want to tell you about longidaza in the treatment of female diseases! I had adhesions after a cesarean section. During the operation and before it, no one warned me about them, and I did not actually do any prophylaxis. And then the problems began: the lower abdomen will ache, then it will tighten. I endured while feeding, could not stand it and went to the doctor. She prescribed 20 longidaza injections for me. I started to be treated with them, and although they are painful, terrible and expensive, they still helped me. From the second week of treatment I began to feel that I no longer had a feeling of tightness. I bought it at the pharmacy near my home, it is very easy to find them.
I don't know about cosmetology, I heard about urology that Longidaza helps men with prostatitis. I was saved from adhesions when I was treating another inflammation of the ovaries. I was tormented by adnexitis, from adolescence I have. Because of this, spikes started. Small, loose so far, but they are there and they interfere, sometimes I feel like they ache. They explained to me in the hospital that Longidaza's adhesions would not remove, this is her function. But she can make them softer. And through the permeable tissues, the drugs will quickly get where they need to and the treatment will go normally. I gave 1 injections every 2 days. Feel better for 4 like. After the course, adhesions do not bother, there are no new ones.