Xeomin. Instructions for use in cosmetology, neurology. Price, analogues

Xeomin is a drug that is used for intramuscular injection. With its help, skin rejuvenation is performed. The main component of the drug is butoloxin. It is an effective remedy in the fight against age-related skin changes.

Composition of the preparation Xeomin

One bottle of the drug contains 100 IU of botulonic type A toxin, 1 mg of human albumin, 4.7 mg of sucrose.

Release form

Available as a lyophilisate. It is a white powder (slight color variations possible). Vials of various dosages: 50 or 100 units. Each bottle is in a separate package. The box contains up to 6 packaged vials.

Pharmacological properties

The drug has a muscle relaxant effect. The study of botulinum toxin was not carried out, since the composition of the drug instantly connects to the nerve endings.

Pharmacodynamics

The composition of the drug selectively affects the nerve endings of cells, while suppressing the appearance of acetylcholine.

The connection of the drug with the nerve endings of cells is characterized by several stages:

1. Connection of a chain of neurotoxins with nerve endings.
2. The process of transition of a neurotoxin into the internal state of nerve endings.
3. The neurotoxin light chain moves into the liquid contents of the nerve endings.
4. Protein breakdown process: SNAP 25 and target protein.

As a result, the muscles exposed to the Xeomin injection relax. A noticeable result occurs within 4 - 6 days after drug administration. The effect of one procedure lasts 3 - 4 months. A longer effect of the drug is also possible. It is individual for each person.

Pros and cons

Positive aspects of Xeomin for cosmetic use:

1. Drug availability. The price is much lower than that of analogues.
2. Profitability. To achieve the goal, a minimum amount of Xeomin is enough.
3. Minimum side effects. Unlike analogues, it can be used for women with violations of the integrity of tissue barriers.
4. The drug retains its properties during long-term storage at room temperature.

Of the negative aspects of the drug, only a short period of exposure to the body can be distinguished. In comparison with analogues, the result from Xeomin injections is less durable. Xeomin has positive reviews from doctors and patients. In their opinion, the drug meets the declared characteristics.

Indications for use in cosmetology

Xeomin has been successfully used in cosmetology since 2008. The developer was the German pharmaceutical company Merz. The main purpose of the drug is to inject it into small muscles. In the field of cosmetology, Xeomin is used to rid the skin of mimic wrinkles.

Botox and Dysport are analogues. Xeomin has an improved formula. It blocks the contraction of the injected muscle.They become relaxed and motionless. As a result, the skin acquires an even structure, wrinkles disappear. The drug is the safest in the botuloxin line. It preserves natural facial expressions. Muscle relaxation occurs gradually over a period of 14 days.

Xeomin, the instructions for the use of which will be described below, is widely used in cosmetology.

Facial areas for which botulinum therapy is used:

• Vertical folds that appear over time on the cheeks;
• sagging tissues;
• changes in the skin in the eye area, crow's feet;
• age-related skin changes in the mouth;
• various kinds of creases.

Xeomin, the instructions for use of which contains a wide list of indications, is intended for women 30-40 years old. The drug is well absorbed at this age. For patients over 40, other drugs will be required. Xeomin injections in this case will serve as an auxiliary measure.

Indications for use in neurology, dosage

Xeomin, the instructions for the use of which will be discussed below, is used for patients with diseases of the nervous system. It is used for the treatment of diseases such as blepharospasm, post-stroke conditions, cervical dystonia.

Cervical dystonia (torticollis)

In this disease, the drug is injected into the small muscles responsible for the position of the head or the muscles that lift the scapula. If necessary, the specialist will prescribe injections in other muscle groups.

Each point of the muscle usually accounts for 0.1 - 0.5 ml of Xeomin. No more than 50 U of the drug is injected into the site of one injection. The use of more than 200 units of Xeomin in one procedure is contraindicated. The specialist can increase the dose to 300 IU only in rare and necessary cases.

Electromyography is often used in the treatment of this disease. It helps to identify the area of ​​the affected muscles.

Blepharospasm

Xeomin injections are used for the circular muscle of the upper and lower eyelids. The dosage starts from 1.25 U. In case of visual impairment, additional injections of the drug are prescribed.

For one procedure, the dosage cannot exceed 100 units. The effect of the drug can be observed after 3 to 4 days. If necessary, the course can be re-assigned. The minimum time between treatments is 6 weeks. Repeated injections are prescribed by a specialist individually for each patient.

Recovering from a stroke

Post-stroke therapy is a long and laborious process. The dosage and number of treatments depends on the amount of muscle affected. It is individual for each patient. Xeomin is used for spasticity of the muscles of the arms after muscle damage due to a stroke.

Average dosages for the defeat of different muscle groups (U):

• ulnar muscle - 40-50;
• wrist - 40;
• brachioradial - 60;
• biceps - 80;
• finger - 10-20.

Contraindications

Xeomin has a number of contraindications, in which its use becomes impossible:

1. Pregnancy and breastfeeding periods.
2. The presence of pathologies of various kinds in acute forms.
3. Individual intolerance to the components that make up the drug.
4. The presence of inflammation at the sites of the proposed injection.
5. The patient is under 18 years of age.
6. Disorders associated with the neuromuscular system.

Instructions for use

The treatment is carried out by a physician experienced in working with botuloxic drugs. Before use, the pharmaceutical product must be dissolved. This action is carried out using a 0.9% sodium chloride solution. To restore Xeomin, you need to spread a sterile towel (preferably paper) on a plastic surface. The syringe is used with a 20-27 gauge meek needle and an oblique cut.

The required amount of sodium chloride is drawn into a syringe and injected into the vial with Xeomin.

It is important that the needle is perpendicular to the rubber stopper.

The formation of foam inside the bottle is unacceptable. For complete dissolution of the drug, the product is gently turned over several times, avoiding sudden shaking. Then take a needle, suitable for injection, and collect the Xeomin solution with it.

The syringe must be new and sterile. If the solution is not drawn into the vial by vacuum, the drug must be disposed of and use a new package.

After reconstitution, the drug solution has a transparent color without any impurities. You need to apply Xeomin within a few minutes after it is dissolved. It is unacceptable to use one solution to several patients. Storage of the drug in a diluted form is impossible. The restoration of the drug should be carried out strictly according to the instructions.

Side effects

Xeomin, the instructions for use of which are discussed above, can cause various side effects. Contributes to the appearance of a negative result of neurotoxin. The severity of the side effect depends on the areas in which the drug is injected. Also from the disease itself.

Adverse reactions in the treatment of blepharospasm:

• dry mouth;
• various kinds of rashes on the body;
• headaches;
• teary eyes or sun intolerance;
• drooping of the eyelid;
• weakening of the muscles of the locomotor system.

Glaucoma may develop, with swelling of the eyes.

Side effects in the treatment of torticollis:

• disorders associated with the musculoskeletal system: pains of various types (back, legs, etc.);
• disorders in the intestine and digestive tract: colic, abdominal pain, dry mouth, nausea, possible vomiting, problems with swallowing food;
• possible redness and inflammation at the injection sites;
• various kinds of skin rashes: psoriasis, rash, exfoliation;
• increased sweating;
• respiratory disorders: bronchitis, runny nose, voice changes, shortness of breath;
• disorders of the cardiovascular system: heart attack, changes in blood pressure, arrhythmia;
• disorders of the nervous system: complete or partial numbness of the limbs, severe pain in the head, the presence of general weakness;
• various allergic reactions: urticaria, Quincke's edema, anaphylactic shock, etc.

Side effects in the treatment of post-stroke conditions:

• severe headaches;
• general muscle weakness;
• increased body temperature;
• deterioration of mood, depression is possible;
• sleep disturbance, insomnia;
• lack of coordination;
• various kinds of rashes on the body;
• hematomas may form at the injection sites.

Side effects during cosmetic procedures:

• headaches;
• itching at the injection sites;
• swelling of the eyes;
• visual impairment;
• bronchitis;
• feeling of a cold;
• dry eyes and intolerance to bright light;
• loss of vision;
• nausea or vomiting

Side effects associated with cosmetology occur within a few days after the procedure.

Overdose

In cases of exceeding the dosage of the injected injection, the reaction of the body may be unpredictable. To avoid undesirable effects, do not use the drug on your own.

Overdose is expressed by the following symptoms:

• increased sweating;
• violation of swallowing functions;
• difficulty speaking;
• paralysis of the muscles of the respiratory system;
• development of pneumonia of the lungs.

In case of paralysis of the muscles of the respiratory system, you must immediately contact a medical institution. The patient is connected to a ventilator. Disconnection from the device occurs when the patient reaches a normal state.

In order to avoid a negative effect, side effects of the drug or serious allergic reactions after the procedure, it is necessary to remain under the supervision of the specialist who performed the injection for some time.

special instructions

The introduction of the drug Xeomin can only be carried out by experienced specialists.

Before the appointment, the doctor must carefully study the patient's medical history, the presence of allergic reactions, the presence or absence of surgical interventions. Avoid getting the drug into the blood vessels. When using Xeomin to get rid of wrinkles do not inject into places marked with ink. The effect of a permanent tattoo is possible.

When treating post-stroke conditions, care should be taken in places such as the carotid artery, esophagus, and upper lungs.

There are several patient conditions in which Xeomin injections are administered with extreme caution:

1. Patients with amyotrophic lateral sclerosis.
2. Patients with muscle atrophy.
3. Patients with trauma resulting in increased bleeding.
4. People on drugs that cause blood clotting.
5. People with neuromuscular dysfunction disorders

Butolinic neurotoxin is able to temporarily block muscle groups. Therefore, in order to avoid a negative result, it is necessary to take seriously the choice of injection site. It is possible for the neurotoxin to spread to distant sites from the injection site. What causes a negative effect.

There are cases when in the treatment of blepharospasm, cervical dystonia or post-stroke conditions, a lethal outcome occurred due to allergic reactions or improper use of the drug.

In the event of side effects, the person undergoing treatment with Xeomin or the people caring for the patient should immediately seek medical help. The first signs for hospitalization are speech or swallowing disorders, breathing disorders.

To avoid severe muscle weakness in neurological patients, treatment with Xeomin is carried out under the constant supervision of specialists. In such cases, the introduction of the drug is carried out only if the effect of therapy outweighs the risks. With increased risks, Xeomin therapy is not possible.

Getting rid of wrinkles is prohibited for patients with a history of aspiration.

The occurrence of anaphylactic shock or any other hypersensitivity reactions means the need to discontinue treatment with this drug and conduct appropriate therapy.

Frequent use of the drug can cause the formation of antibodies in the body, which subsequently reduce the effectiveness of Xeomin. With the introduction of any therapeutic proteins, there is a high probability of the appearance of immunogenicity.

The use of the drug often causes the development of dysphagia. The specialist is obliged to warn the patient about the consequences and possible medical intervention.

Patients who are at risk of developing glaucoma should be aware that Xeomin has an anticholinergic effect on the body. Particular attention should be paid to the introduction of the drug into the lower eyelid area.as well as avoiding injections near the muscle that lifts the upper eyelid.

The drug may adversely affect the ability to drive a car or when working on hazardous objects. In order to avoid unpleasant situations, after the injection of Xeomin, you should refrain from driving.

Application during pregnancy and lactation

The use of the drug Xeomin during pregnancy is strictly prohibited according to the rules in the instructions. Treatment during feeding is also not possible. If you need Xeomin therapy, you must stop breastfeeding.

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Childhood use

The use of the drug is unacceptable for persons under the age of majority. Before using Xeomin, you must read the instructions.

Use in the elderly

Elderly people over 60 years old do not need Xemin therapy. The drug has no clinical experience in the treatment of people in this category. Studies show that older people need to be treated with other drugs because Xeomin does not give the desired effect.

Drug interactions

This muscle relaxant should be used with caution. Contraindicated exposure to drug groups such as aminoglycosides and spectinomycins. With the simultaneous treatment with Xeomin and other drugs, the expected effect can be significantly reduced.

Analogs

Xeomin's analogues are such drugs as Dysport, Botox, Refinex, Zentox, Lantoks. They are similar in principle of action. Manufactured by various pharmaceutical companies.

The price of these medicines is also different. All analogues are used in both cosmetology and neurology. Cosmetology clinics use absolutely all analogues of the drug in their application, choosing the right one for each patient.

Terms and conditions of storage

The diluted solution is applied within 24 hours after preparation. In a closed form, Xeomin vials can be stored for 3 years from the date of production. The temperature regime of storage of the drug is from 2 to 8 ° C.

Terms of dispensing from pharmacies

The drug Xeomin is dispensed in pharmacies only with a doctor's prescription.

Xeomin price in pharmacies

In Moscow and St. Petersburg, you can see different prices for the drug.

Reviews of cosmetologists about Xeomin

According to experts, the drug Xeomin, unlike its counterparts, has the best composition. It causes fewer allergic reactions and fewer side effects.

It contains only purified components, which virtually eliminates the appearance of unwanted results. This drug has been used since 2001. Currently, injections with botuloxic drugs have become very popular not only among women, but also among men.

The tool is very much in demand by cosmetology clinics. Cosmetologists prefer the use of Xeomin to other analogs, despite many of the adverse reactions described in the instructions. They actively advise his patients. The latter also note the high efficiency of the drug and leave good reviews about it.

Article design: Mila Friedan

Video about Xeomin

Xeomin injections for the face: