Glutathione - what it is, benefits for the body. Instructions for use in cosmetology, reviews of doctors

The active substance glutathione fights free radicals. Instructions for use of the drug describe the drug as indispensable for many age-related diseases and changes in the body.

Functions of glutathione in the human body

The antioxidant glutathione is present in all cells of the human body. Consists of 3 important amino acids - monoaminodicarboxylic glutamic, amino-mercaptopropane, aminoethane, which perform important work, protecting the cells of the body from free radicals.

As well as:

• promotes the revival of antioxidants missing in the body;
• enhances the work of certain pharmacological agents and organic vitamins;
• neutralizes the negative effects of toxic compounds in the body;
• removes toxic substances from the body;
• corrects impaired renal function;
• helps to maintain muscle tone;
• regulates the function of the stomach;
• corrects lipid metabolism;
• regulates the absorption of water and electrolytes in the body;
• keeps white blood cells from being destroyed;
• promotes the preservation of immune cells;
• promotes detoxification processes in the liver;
• regulates the death of cancer cells.

Glutathione test

Plasma studies for the amount of the antioxidant glutathinone should be done if serious pathologies are suspected in the body.

A genetic blood test should be done for the enzyme glatathione transferase, which has subdivisions:

• theta-1 glathution S - transferase - when this enzyme is absent in the gene, the body loses its ability to get rid of harmful substances, which increases the likelihood of developing cancerous growths and disrupting the functioning of the cardiovascular system;
• mu-1 glutathione S - transferase - the absence of an enzyme in the DNA site helps to reduce the accumulation of toxic substances from the body, which leads to pathological processes in the body;
• pi-1 glutathione S - transferase - deficiency of amino acids in white blood cells, affects the lack of oxygen in the body and increases the risk of neoplasms.

Reasons for a lack of glutathione in the body

Glutathione (the instructions for use of the drug do not describe the reasons for the lack of amino acids in the body) is a nonessential amino acid that the body can synthesize during metabolism from nutrients and other organic compounds inside the body.

The main cause of tripeptide deficiency is:

• lack of protein foods in the diet;
• synthetic products;
• hazardous environment;
• abrasives, fragrances, volatile organic compounds used in daily life;
• a large amount of pesticides in food;
• a large number of salts of nitric acid;
• uncontrolled use of antibacterial agents;
• energy in the form of electromagnetic waves;
• the genes of the system for neutralizing toxic substances in the body do not work;
• age-related changes.

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Glutathione Deficiency Symptoms

Glutathione (the instructions for use of the drug do not explain how there is a lack of amino acids in the body) is an enzyme, the lack of which in the body has its manifestations:

• premature aging of the body;
• asthenic-neurotic syndrome;
• suppressed psycho-emotional state;
• passivity;
• manifestation of indifference and indifference to the environment;
• long-term diseases caused by opportunistic organisms;
• seasonal allergic reactions;
• food intolerance;
• rheumatoid arthritis;
• systemic lupus erythematosus;
• systemic sclerosis;
• skin autoimmune pathologies - dermatitis, eczema, psoriatic rash;
• white spot disease;
• chronic renal failure;
• prolonged inflammatory process in the liver;
• pathological formations without progression;
• tumors with uncontrolled growth and development of malignant cells.

Consequences of a lack of antioxidant

The instructions for the use of the drug Glutathione do not tell what consequences can be expected in case of insufficient antioxidant in the human body.

The enzyme plays a very important role in the life of the body as a whole, and its lack sometimes leads to an irreparable result:

• the accumulation of unstable molecules in the body, which have a negative effect on the vital functions of the body;

  

• leads to both external and internal early aging of the body;
• the emergence of acute, and later chronic formation of reactive oxygen species, which in turn suppresses the immune system;
• the formation of cellular hostility within the body, which leads to a decrease in the level of leukocytes;
• decrease in the body of tocol derivatives;
• a decrease in glutathione leads to a lack of ascorbic acid;
• connective tissue begins to function poorly;
• the number of inflammatory pathologies in the body increases, which leads to hyperemia of tissues and organs;
• leads to the formation of autoimmune aggression within the body;
• psycho-emotional tension appears;
• asthenic condition;
• destruction of the myelin layer of nerve endings;
• polyradiculoneuritis;
• the occurrence of polyneuropathy;
• there is a steady decrease in mental activity;
• leads to trembling paralysis;
• may manifest as the destruction of brain cells or Alzheimer's disease;
• affects disturbances in the work of the glands of external secretion;
• provokes long-term inflammatory pathologies of the respiratory system;
• decrease in the number of macrophages;
• a decrease in glutathione increases the risk of malignant neoplasms in the body;
• causes irregular breathing during sleep with respiratory arrest;
• during gestation leads to fetal hypoxia;
• lack of glutathione can provoke miscarriages and premature birth;
• provokes the occurrence of diabetic encephalopathy;
• lack of enzyme leads to impaired blood circulation in liver cells, which leads to organ damage;
• damages the circulatory system of the kidneys, which provokes a violation of the production of red blood cells;
• the content of extracellular fluid increases;
• leads to the appearance of arrhythmia;
• high blood pressure appears;
• provokes increased work of the glands of external secretion;
• the less glutathione, the less the production of the hormone melanin;
• blanching of the optic nerve occurs;
• increases intraocular pressure;
• provokes the appearance of autoimmune diseases.

Glutathione Replenishment Methods

There are several ways to replenish the missing amount of glutathione coenzyme in the body:

1.apply pharmacological preparations with glutathione;

2.use of antioxidants that provoke the formation of glutathione:

• fatty vitamin-like lipoic acid;
• organic compound of ascorbic acid;
• a fat-soluble tocol compound;
• element from sulfuric acid waste - selenium;
• flavin immunonucleotides;
• pyridoxamine;
• hydroxocobalamin;
• polyglutamate B9;
• organic matter alpha amino acids;

3. Eat foods rich in the antioxidant glutathione.

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Glutathione in foods

To replenish the amount of glutathione in the body, you should eat the following foods:

• beans, lentils, beans, peas;
• tomatoes;
• Brussels sprouts;
• head white cabbage;
• parsley, dill, basil, spinach;
• capsicum bell pepper;
• meat (beef, chicken, turkey);
• medium-sized sea fish;
• squid;
• lobsters;
• lobster;
• shrimp;
• offal;
• unrefined extra virgin olive oil;
• unrefined linseed oil;
• corn oil;
• walnuts;
• shrub seed common almonds;
• oilseed sunflower seeds;
• yellow ginger;
• ceylon cinnamon;
• field anise;
• oatmeal;
• polished rice;
• cereal;
• wheat bran;
• bluegrass seeds;
• goat milk;
• feta cheese from goat milk;
• dairy products;
• cottage cheese;
• milk powder;
• lemon, orange, tangerine;
• eggs.

Eating foods that contain an antioxidant will help maintain enzyme levels at the right levels. In the case when the amount of glutathione in the blood is very low, then pharmacological agents containing an amino acid should be used.

Glutathione dosage form

Glutathione (the instructions for use of the drug describe the release form of the pharmacological agent) is available in the form of a powder for injection, both intravenous and intramuscular.

1 bottle of the drug contains 300 mg, 600 mg, 1800 mg of the drug, which contains the tripeptide glutamylcysteinylglycine. Fine powder, which the pharmaceutical industry produces by soft drying, tends to persist for a long time.

Instructions for the use of Glutathione

Glutathione (instructions for use give clear recommendations on how to use the drug) is only an injection drug. It can not be diluted with water and taken orally, it is injected intravenously with a dropper and jet - injections and intramuscular administration of the drug.

Intravenously:

1.In the form of jet injection:

• powder 300 mg or 600 mg in a vial should be dissolved using a syringe with a medical liquid or isotic solution for infusion;
• the resulting liquid must be filled with a syringe and slowly inserted into a vein;
• you need to use the drug immediately after preparation, it cannot be stored;

2.In the form of droppers, the agent should be prescribed for serious liver pathologies and with a decrease in the toxicity of chemotherapy on the body:

• for inflammatory pathologies of the liver, the drug must be used from 1200 mg to 1400 mg of the drug diluted in isotonic sodium chloride solution - 500 mg;
• drip, slowly;
• the course of therapy is 1 month in the form of droppers;
• further - by appointment of an infectious disease doctor;
• with liver damage, as a result of alcohol dependence - 1800 mg of medicinal powder should be diluted in 500 mg of a 5% dextrose solution;
• drip treatment must be continued for 2-4 weeks;
• further in accordance with the recommendations of a narcologist;
• proliferation of the connective tissue of the liver due to alcoholism - the drug Glutathione at a dose of 1200 mg must be used after dissolving the drug in an isotonic sodium chloride solution of 500 ml;
• drip, slowly - at least 30 minutes;
• the duration of drip therapy is 1 month;
• for fatty liver infiltration - medicinal powder, in the amount of 1200 mg must be diluted in 500 ml of medical distilled liquid;
• should be administered slowly, daily - 1 time;
• the course of treatment is 1 month;
• when undergoing a course of chemotherapy, 1200 mg - 1800 mg of the drug Glutathione should be used, depending on the liver load (which must be determined by analysis for liver enzymes);
• the required dose of the medicinal powder must be dissolved in 100 ml of 5% dextrose solution;
• the duration of the drip procedure is 15 minutes;
• further, from the 5th day of Glutathione therapy, it is necessary to switch to intramuscular injections of the drug - 0.6 g of the drug;
• the drug Glutathione must be diluted in 5 ml of 9% isotonic sodium chloride solution;
• intramuscular therapy course - 4 days;

3.for intramuscular injection:

• 300 mg or 600 mg of Glutathione should be diluted in 2.5 ml or 5 ml of isotonic sodium chloride solution;
• the diluted drug must be drawn into a syringe and injected intramuscularly;
• the drug should not precipitate - only a clear solution can be injected into the muscle;
• the duration of therapy is determined by a gastroenterologist, surgeon or therapist;
• Glutathione at a dosage of 1200 mg and 1800 mg cannot be administered intramuscularly.

Indications, contraindications, side effects from the use of Glutathione

Glutathione, like any pharmacological drug, has indications for use, side effects and contraindications for use.

The indications for the prescription of the drug Glutathione are:

• with long-term inflammatory liver diseases (of various origins) in combination therapy with other drugs;
• use glutathione with anticonvulsant drugs (to protect the liver from damage);
• with anti-tuberculosis therapy, you need to undergo a course of Glutathione therapy;
• with autoimmune pathologies of the body - lupus, scleroderma, vasculitis, Sjogren's syndrome, rheumatism, vitiligo;
• should be prescribed for type 1 and type 2 diabetes mellitus;
• with Alzheimer's disease;
• in the treatment of discirculatory and dysmetabolic encephalopathy;
• allergic skin reactions in the form of dermatitis, eczema require the appointment of a drug;
• asthenic conditions;
• vegetative-vascular dystonia;
• menopause;
• psycho-emotional stress;
• depressive conditions;
• malignant neoplasms;
• chronic renal failure;
• hematological diseases with a low level of leukocytes;
• with insufficient production of red blood cells.

Contraindications

The main contraindication to the administration of Glutathione is a personal, negative reaction of the body to the main active ingredient of the drug. Also, you can not use the drug under the age of 12 years. Caution should be exercised when using Glutathione over the age of 60, in which case it is necessary to adjust the dose of the medication.

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Adverse drug manifestations

Side effects are possible when using Glutathione:

• arterial hypotension;
• arrhythmia;
• bradycardia;
• disorders of the digestive system in the form of constipation or loosening of the stool.

All unforeseen negative manifestations from taking Glutathione disappear after you stop taking the drug.

Application during pregnancy and lactation

Do not use Glutathione during gestation. If there is a need to use Glutathione during breastfeeding, lactation is stopped.

Preparations containing an antioxidant, analogs

The pharmaceutical industry produces generics of the drug Glutathione:

1. Hepaval:

• the preparation contains the tripeptide glutamylcysteinylglycine 0.6 g, isotonic sodium chloride solution - 1 bottle;
• tripeptide glutamylcysteinylglecine 0.6 g, 4 ml of medical water - 1 ampoule;
• for complex pathological processes, 0.6 g - 1.2 g of the drug should be prescribed once a day;
• should be used in the form of drip injections;
• in case of diseases of moderate severity, it is necessary to use the drug intramuscularly;
• drug dose from 0.3 g to 0.6 g - 1 time per day;
• the course and duration of therapy depends on the underlying disease.

2. Acyzol capsules:

• the main active ingredient of the drug is vinylimidazole zinc diacetate, milk sugar, fatty powder, polysorb, stearic acid with calcium, titanium dioxide, hydrolyzed collagen, sulfosalt, carmazin, triarylmethane dye, black shiny granulate, methylparaben, propylparaben;
• the drug Atsizol should be taken orally with a large volume of liquid;
• in order to prevent intoxication, the drug should be used - 1 capsule before exposure to chemotherapy;
• treatment of acute liver pathologies - 1 capsule - 4 times a day - the first day;
• then you should take the drug 1 pc. morning and evening, during the week.

3. Tad 300 injectable preparation:

• the preparation contains the antioxidant glutathione, sodium chloride solution;
• in case of pathological conditions of moderate severity, 1-2 ampoules (which corresponds to 4-8 ml of solution) should be used intravenously or intramuscularly;
• in severe diseases, 4 ampoules of the drug should be diluted in 500 ml of isotonic sodium chloride solution and administered by drip into a venous vessel;
• the duration of therapy is determined by the therapist.

4. Glutathione complex capsules:

• the preparation contains a finely dispersed substance extract from Brussels sprouts, l-glutamate, an active phytochemical substance indole 3 carbinol;
• the complex preparation should be used in 1 pc. - in the morning, afternoon, evening, before meals;
• the course of therapy is 30 days.

5. Glutathione-L preparation in capsules:

• the main active ingredients of the preparation are the organic yeast-like microelement selenium, molybdenum glycinate, glutathione precursor acetyl-cysteine;
• for the prevention of glutathione deficiency in the body, you should take 1 capsule - 1 time per day, during meals;
• for treatment - you need to take the drug 4 times a day;
• the duration of therapy is 30 days.

To restore the required amount of glutathione, an antioxidant, in the body, the drug Glutathione should be used in accordance with the recommendations of the instructions for use. This is the only way not to harm the body, but to prevent many diseases.

Article design: Mila Friedan

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